Welcome to your training resource for Nyxoid

Naloxone has been used in routine practice for more than 40 years to reverse the effects of opioid overdose and in therapeutic situations.¹ It reverses the effects of opioids (including respiratory depression) by competing directly with them at the opioid receptor.¹

The risk of death can be reduced with the administration of naloxone as soon as an overdose is recognised. Naloxone is acknowledged as an important treatment option for opioid overdose and is included in the WHO Model List of Essential Medicines that countries should fund and supply.

In recent years, measures have been implemented in certain European countries to expand access to naloxone among opioid users and other potential ‘first responders’ in overdose situations, often through take-home naloxone (THN) programmes.

Nyxoid may be dispensed as part of a THN programme or directly from a physician. THN programmes are designed to increase availability of naloxone in places where overdose are most likely to occur. Training is an essential part of THN programmes.

Nyxoid is a single-dose nasal spray of naloxone for emergency use after an overdose of opioid drugs (such as heroin or morphine).² Signs of overdose include pinpoint pupils, abnormally slow and irregular breathing, severe sleepiness and unresponsiveness to touch or loud noises.³

Nyxoid can be used in adults and adolescents from 14 years of age.² It contains the active substance naloxone and is given as a spray into the nose. Each pack contains 2 sprays (2 single doses). Nyxoid is not a substitute for emergency medical care. Nyxoid should be carried by anyone at risk of overdosing on an opioid. Carers, such as close family or friends, should know where to find Nyxoid in case of emergency.¹